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. 2008 Jun;71(6):1027-31.
doi: 10.1021/np8001145. Epub 2008 May 31.

Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum

Chien-Chang Wu  1 , Ming-Hong Yen, Shyh-Chyun Yang, Chun-Nan Lin
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Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum

Chien-Chang Wu et al. J Nat Prod. 2008 Jun.

Abstract

A new phloroglucinol, hyperielliptone HA (1/1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB (2/2a), and two new xanthonolignoids, hyperielliptones HC (3) and HD (4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/1a and 2/2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/ 2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase.

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