Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection
- PMID: 18518716
- PMCID: PMC4190025
- DOI: 10.3171/JNS/2008/108/6/1132
Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection
Abstract
Object: Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies.
Methods: The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are > or = 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression.
Results: Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006).
Conclusions: In the FIA study, among the affected patients' FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening.
Figures
Comment in
-
Detection of aneurysms.J Neurosurg. 2008 Jun;108(6):1130-1. doi: 10.3171/JNS/2008/108/6/1130. J Neurosurg. 2008. PMID: 18518715 No abstract available.
References
-
- Atkinson JL, Sundt TM, Jr, Houser OW, Whisnant JP. Angiographic frequency of anterior circulation intracranial aneurysms. J Neurosurg. 1989;70:551–555. - PubMed
-
- Chapman AB, Rubinstein D, Hughes R, Stears JC, Earnest MP, Johnson AM, et al. Intracranial aneurysms in autosomal dominant polycystic kidney disease. N Engl J Med. 1992;327:916–920. - PubMed
-
- Edwards A, Taylor GW. Ehlers-Danlos syndrome with vertebral artery aneurysm. Proc R Soc Med. 1969;62:734–735. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases