IKKbeta/NF-kappaB and the miscreant macrophage
- PMID: 18519650
- PMCID: PMC2413023
- DOI: 10.1084/jem.20081056
IKKbeta/NF-kappaB and the miscreant macrophage
Abstract
Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorders of chronic inflammation, infection, and cancer. New studies now show a role for the NF-kappaB activator IKKbeta in promoting an alternative, immunosuppressive pattern of macrophage activation, which limits the cell's tumoricidal and bactericidal capacities. As cancers and pathogens may have evolved multiple mechanisms to manipulate macrophages for their own survival, is there anything we can do about it?
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Comment on
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"Re-educating" tumor-associated macrophages by targeting NF-kappaB.J Exp Med. 2008 Jun 9;205(6):1261-8. doi: 10.1084/jem.20080108. Epub 2008 May 19. J Exp Med. 2008. PMID: 18490490 Free PMC article.
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An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation.J Exp Med. 2008 Jun 9;205(6):1269-76. doi: 10.1084/jem.20080124. Epub 2008 May 19. J Exp Med. 2008. PMID: 18490491 Free PMC article.
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