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. 2008 Aug;52(8):2950-4.
doi: 10.1128/AAC.01672-07. Epub 2008 Jun 2.

Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey

Amélie Carrër  1 , Laurent Poirel, Haluk Eraksoy, A Atahan Cagatay, Selim Badur, Patrice Nordmann
Affiliations

Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey

Amélie Carrër et al. Antimicrob Agents Chemother. 2008 Aug.

Abstract

The first outbreak of carbapenem-resistant Klebsiella pneumoniae isolates producing the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 is reported. The 39 isolates belonged to two different clones and were collected at the University Hospital of Istanbul, Turkey, from May 2006 to February 2007, and they coproduced various beta-lactamases (SHV-12, OXA-9, and TEM-1 for clone A and CTX-M-15, TEM-1, and OXA-1 for clone B).

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Figures

FIG. 1.
FIG. 1.
Pulsed-field gel electrophoresis patterns of OXA-48-producing K. pneumoniae isolates. Lanes: 1 to 3, three isolates of clone A harboring the blaOXA-48, blaOXA-9, blaSHV-12, and blaTEM-1 genes; 4 to 6, three isolates of clone B harboring the blaOXA-48, blaOXA-1, blaCTX-M-15, and blaTEM-1 genes; M, molecular mass markers.
FIG. 2.
FIG. 2.
Schematic representation of Tn1999.2 described for clone B. The coding regions are represented as boxes, with arrows indicating their transcription orientations.
FIG. 3.
FIG. 3.
Nucleotide sequence of the −35 and −10 putative promoter regions within IS1999 described for clone A (A) and clone B (B). The left inverted repeats (IRL) of IS1999 and of IS1R are shaded in gray, and the −35 and −10 putative sequences are underlined. The tnpA transposase gene is indicated.
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References

    1. Aktas, Z., C. Bal Kayacan, I. Schneider, B. Can, K. Misilli, and A. Bauernfeind. 2008. Carbapenem-hydrolyzing oxacillinase OXA-48 persists in Klebsiella pneumoniae in Istanbul, Turkey. Chemotherapy 54:101-106. - PubMed
    1. Aubert, D., T. Naas, C. Héritier, L. Poirel, and P. Nordmann. 2006. Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of β-lactam resistance genes. J. Bacteriol. 188:6506-6514. - PMC - PubMed
    1. Bradford, P. A., C. Urban, N. Mariano, S. J. Projan, J. J. Rahal, and K. Bush. 1997. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC β-lactamase, and the loss of an outer membrane protein. Antimicrob. Agents Chemother. 41:563-569. - PMC - PubMed
    1. Bratu, S., D. Landman, R. Haag, R. Recco, A. Eramo, M. Alam, and J. Quale. 2005. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch. Intern. Med. 165:1430-1435. - PubMed
    1. Cagnacci, S., L. Gualco, S. Roveta, S. Mannelli, L. Borgianni, J. D. Docquier, F. Dodi, M. Centanaro, E. Debbia, A. Marchese, and G. M. Rossolini. 2008. Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-beta-lactamase: first Italian outbreak. J. Antimicrob. Chemother. 61:296-300. - PubMed

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