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Randomized Controlled Trial
. 2008 Jul;27(7):656-8.
doi: 10.1097/INF.0b013e318168d29e.

Efficacy of pentavalent human-bovine (WC3) reassortant rotavirus vaccine based on breastfeeding frequency

Michelle G Goveia  1 , Mark J DiNubile, Michael J Dallas, Penny M Heaton, Barbara J Kuter; REST Study Team
Affiliations
Randomized Controlled Trial

Efficacy of pentavalent human-bovine (WC3) reassortant rotavirus vaccine based on breastfeeding frequency

Michelle G Goveia et al. Pediatr Infect Dis J. 2008 Jul.

Abstract

The efficacy of a live, oral, pentavalent rotavirus vaccine against G1-4 rotavirus gastroenteritis (RVGE) was retrospectively assessed based on breastfeeding frequency among 5098 infants in a placebo-controlled trial. The efficacy against any RVGE severity for infants never breastfed, sometimes breastfed, or exclusively breastfed was 68.3%, 82.2%, and 68.0%, respectively. The efficacy against severe RVGE was 100%, 95.4%, and 100%, respectively. Breastfeeding did not seem to adversely impact the efficacy of pentavalent rotavirus vaccine.

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