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Randomized Controlled Trial
. 2008 Jun 1;48(2):190-5.
doi: 10.1097/QAI.0b013e3181775926.

A cluster-randomized trial of provider-initiated (opt-out) HIV counseling and testing of tuberculosis patients in South Africa

Diana S Pope  1 , Andrea N Deluca, Paula Kali, Harry Hausler, Carol Sheard, Ebrahim Hoosain, Mohammad A Chaudhary, David D Celentano, Richard E Chaisson
Affiliations
Randomized Controlled Trial

A cluster-randomized trial of provider-initiated (opt-out) HIV counseling and testing of tuberculosis patients in South Africa

Diana S Pope et al. J Acquir Immune Defic Syndr. .

Abstract

Objective: To determine whether implementation of provider-initiated human immunodeficiency virus (HIV) counseling would increase the proportion of tuberculosis (TB) patients who received HIV counseling and testing.

Design: Cluster-randomized trial with clinic as the unit of randomization.

Setting: Twenty, medium-sized primary care TB clinics in the Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape Province, South Africa.

Subjects: A total of 754 adults (18 years and older) newly registered as TB patients in the 20 study clinics.

Intervention: Implementation of provider-initiated HIV counseling and testing.

Main outcome measures: Percentage of TB patients HIV counseled and tested. SECONDARY: Percentage of patients with HIV test positive, and percentage of those who received cotrimoxazole and who were referred for HIV care.

Results: : A total of 754 adults newly registered as TB patients were enrolled. In clinics randomly assigned to implement provider-initiated HIV counseling and testing, 20.7% (73/352) patients were counseled versus 7.7% (31/402) in the control clinics (P = 0.011), and 20.2% (n = 71) versus 6.5% (n = 26) underwent HIV testing (P = 0.009). Of those patients counseled, 97% in the intervention clinics accepted testing versus 79% in control clinics (P = 0.12). The proportion of patients identified as HIV infected in intervention clinics was 8.5% versus 2.5% in control clinics (P = 0.044). Fewer than 40% of patients with a positive HIV test were prescribed cotrimoxazole or referred for HIV care in either study arm.

Conclusions: Provider-initiated HIV counseling significantly increased the proportion of adult TB patients who received HIV counseling and testing, but the magnitude of the effect was small. Additional interventions to optimize HIV testing for TB patients urgently need to be evaluated.

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Figures

FIGURE 1
FIGURE 1
Summary of TB patients excluded from study analysis * Died, transferred or moved out < 14 days after TB registration or TB Rx start, whichever was more inclusive
FIGURE 2
FIGURE 2
Proportion of TB patients that received HIV counseling and testing by control and intervention clinics ---- Study mean proportion of TB patients HIV counseled (0.138)
See this image and copyright information in PMC

References

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