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Case Reports
. 1991 Feb;80(2):259-61.
doi: 10.1111/j.1651-2227.1991.tb11845.x.

Isolated ACTH deficiency with absent response to corticotrophin-releasing factor--41. Evidence for a primary pituitary defect

S H Murch  1 , E P Carter, S Tsagarakis, A Grossman, M O Savage
Affiliations
Case Reports

Isolated ACTH deficiency with absent response to corticotrophin-releasing factor--41. Evidence for a primary pituitary defect

S H Murch et al. Acta Paediatr Scand. 1991 Feb.

Abstract

An 8-year-old girl presenting in hypoglycaemic coma was shown to have isolated deficiency of adrenocorticotrophic hormone (ACTH) secretion. Failure to secrete ACTH in response to intravenous administration of synthetic ovine corticotrophin-releasing factor (CRF-41) suggests that this disorder was due to a primary pituitary defect, rather than of hypothalamic origin.

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