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Review
. 2008 Jul;9(7):569-74.
doi: 10.1038/nrm2426. Epub 2008 Jun 4.

Extra-chromosomal elements and the evolution of cellular DNA replication machineries

Adam T McGeoch  1 , Stephen D Bell
Affiliations
Review

Extra-chromosomal elements and the evolution of cellular DNA replication machineries

Adam T McGeoch et al. Nat Rev Mol Cell Biol. 2008 Jul.

Abstract

DNA replication is fundamental to the propagation of cellular life. Remarkably, the bacterial replication machinery is distinct from that used by archaea and eukaryotes. In this article, we discuss the role that lateral gene transfer by extra-chromosomal elements might have had in shaping the replication machinery and even modulating the manner in which host cellular genomes are replicated.

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