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Review
. 2008 Sep;15(3):657-64.
doi: 10.1677/ERC-08-0019. Epub 2008 Jun 4.

Integrins in prostate cancer progression

Hira Lal Goel  1 , Jing Li, Sophia Kogan, Lucia R Languino
Affiliations
Review

Integrins in prostate cancer progression

Hira Lal Goel et al. Endocr Relat Cancer. 2008 Sep.

Abstract

Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.

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Conflict of interest statement

Declaration of interest

The authors declare that there is no conflict of interest that would prejudice the impartiality of this work.

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