doi: 10.1093/nar/19.13.3549.
Curved DNA without AA/TT dinucleotide step
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- PMID: 1852605
- PMCID: PMC328378
- DOI: 10.1093/nar/19.13.3549
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Curved DNA without AA/TT dinucleotide step
Nucleic Acids Res.
.
Free PMC article
Abstract
The evidence is accumulating that dinucleotide steps other than AA/TT affect DNA flexure of AnTm (m + n greater than = 4) containing fragments. However, it is not clear whether macroscopic DNA flexure without AA/TT steps might occur. In this paper we demonstrate the anomaly in electrophoretic mobility of non AA/TT repetitive DNA sequences which is a function of sequence phasing. Therefore, our results show that PyPu (TA) and AG/CT steps, angulary separated by close to 180 degrees from Pu/Py (GC) and GG/CC steps, bend DNA, even in the absence of AnTm tracts.
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