On the use of a continuous metabolic syndrome score in pediatric research

Abstract

Background: The constellation of elevated levels of abdominal adiposity, blood pressure, glucose, and triglycerides and lowered high-density lipoprotein-cholesterol has been termed the metabolic syndrome. Given the current pediatric obesity epidemic, it is perhaps not surprising that recent reports suggest the emergence of the metabolic syndrome during childhood and adolescence. The aim of this paper is to provide an overview of the derivation and utility of the continuous metabolic syndrome score in pediatric epidemiologic research.

Methods/design: Data were generated from published papers related to the topic.

Conclusion: Although there is no universal definition in children or adolescence, recent estimates indicate that approximately 2-10% of youth possess the metabolic syndrome phenotype. Since there is no clear definition and the prevalence rate is relatively low, several authors have derived a continuous score representing a composite risk factor index (i.e., the metabolic syndrome score). This paper provides an overview of the derivation and utility of the continuous metabolic syndrome score in pediatric epidemiological research.

Figure 1

Illustrative example of the age-, sex-, and race-standardized Z score used in the derivation of the metabolic syndrome score. See table 2 for abbreviations and measured values.