Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2008 Jun 6;102(11):1295-7.
doi: 10.1161/CIRCRESAHA.108.178061.

Teed off: cardiac conduction system development requires T-box transcription factors

Katherine E Yutzey
Editorial

Teed off: cardiac conduction system development requires T-box transcription factors

Katherine E Yutzey. Circ Res. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure. T-box transcription factors expressed in the heart
Tbx2 and Tbx1 subfamilies are represented with differential transcriptional regulatory functions in cell proliferation, conduction system specification, chamber maturation and heart morphogenesis.
See this image and copyright information in PMC

Comment on

References

    1. Bakker ML, Boukens BJ, Mommersteeg MTM, Brons JF, Wakker V, Moorman AFM, Christoffels VM. Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res. 2008;102:XXX–XXX. - PubMed
    1. Hoogaars WMH, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LYE, Bakker ML, Clout DE, Wakker V, Barnett P, Revesloot JH, Moorman AFM, Verheijck EE, Christoffels VM. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007;21:1098–1112. - PMC - PubMed
    1. Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 2002;16:1234–1246. - PMC - PubMed
    1. Harrelson Z, Kelly RG, Goldin SN, Gibson-Brown JJ, Bollag RJ, Silver LM, Papaioannou VE. Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004;131:5041–5052. - PubMed
    1. Li QY, Newbury-Ecob RA, Terrett JA, Wilson DI, Curtis AR, Yi CH, Gebuhr T, Bullen PJ, Robson SC, Strachan T, Bonnet D, Lyonnet S, Young ID, Raeburn JA, Buckler AJ, Law DJ, Brook JD. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet. 1997;15:21–29. - PubMed

MeSH terms