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Comment
. 2008 Jun;14(6):815-6.
doi: 10.1016/j.devcel.2008.05.011.

Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor

Paloma García  1 , Jon Frampton
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Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor

Paloma García et al. Dev Cell. 2008 Jun.
Free article

Abstract

MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor MYB (or c-Myb).

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