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Review
. 2008 Sep;29(3):391-414, viii.
doi: 10.1016/j.ccm.2008.03.007.

Genetics of sarcoidosis

Joachim Müller-Quernheim  1 , Manfred Schürmann, Sylvia Hofmann, Karoline I Gaede, Annegret Fischer, Antje Prasse, Gernot Zissel, Stefan Schreiber
Affiliations
Review

Genetics of sarcoidosis

Joachim Müller-Quernheim et al. Clin Chest Med. 2008 Sep.

Abstract

Sarcoidosis is a multigenic and multifactorial disease. Predisposing genes have been identified and fast progress in molecular technologies including systematic genome-wide association studies and large-scale resequencing will aid the discovery of further risk loci and variants. The exploration of the molecular epidemiology of genetic variants in the pathogenesis of sarcoidosis will allow an assessment of their prognostic usefulness. To this end, different granulomatous disorders of known and unknown etiology should be investigated jointly by genetic, immunobiological, and proteomic approaches. The definition of individual genetic risk profiles in sarcoidosis and other chronic inflammatory disorders seems achievable and a useful route for clinical translation.

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