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. 2008 Jun;17(6):596-604.
doi: 10.1177/0961203307088006.

Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children

L A Ramírez Gómez  1 O Uribe UribeO Osio UribeH Grisales RomeroM H CardielD WojdylaB A Pons-EstelGrupo Latinoamericano de Estudio del Lupus (GLADEL)Luis J CatoggioEnrique R SorianoPatricia M ImamuraJorge A ManniSebastián GrimaudoJudith SaranoJosé A Maldonado-CoccoMaria S ArriolaGraciela GómezMercedes A GarcíaAna Inés MarcosJuan Carlos MarcosHugo R ScherbarthPilar C MarinoEstela L MottaCristina DrenkardSusana GamronSandra BuliubasichCarlos M OnettiFrancisco CaeiroAlejandro AlvarellosVerónica SauritSilvana GentilettiNorberto QuagliattoAlberto A GentilettiDaniel MachadoMarcelo AbdalaSimón PalatnikGuillermo A BerbottoCarlos A BattagliottiEmilia SatoElaine M C SellaAlexandreW S SouzaLilian T Lavras CostallatManoel Barros BertoloIbsen Bellini CoimbraEduardo Ferreira Borba NetoEloisa BonfáJoão Carlos TavaresBrenolRicardo XavierTamara MucenicFernando de Souza CavalcantiAngela Luzia Branco DuarteCláudia Diniz Lopes MarquesNilzio Antonio Da SilvaAna Carolina de O e SilvaTatiana Ferracine PachecoJosé Fernando Molina-RestrepoJavier Molina-LópezAntonio Iglesias-GamarraAntonio Iglesias-RodríguezEduardo Egea-BermejoRenato A Guzmán-MorenoJosé F Restrepo-SuárezMarlene Guibert-ToledanoGil Alberto Reyes-LlerenaLoreto MassardoNéstor GarecaSergio JacobelliOscar J NeiraLeonardo R GuzmánAbraham Garcia-KutzbachClaudia CastellanosErwin CajasVirginia Pascual-RamosLeonor A Barile-FabrisJuan Manuel Miranda-LimónMary-Carmen AmigoLuis H SilveiraIgnacio García De La TorreGerardo Orozco-BarocioMagali L Estrada-ContrerasMaria Josefina Sauza del PozoLaura E Aranda BacaAdelfia Urenda QuezadaGuillermo F Huerta-YáñezEduardo M Acevedo-VásquezJosé Luis Alfaro-LozanoJorge M Cucho-VenegasMaria Inés SegamiCecilia P ChungMagaly Alva-LinaresIsaac AbadiRosa Chacón-DíazSoham Al Snih Al SnihMaria H Esteva-SpinettiJorge Vivas
Affiliations

Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children

L A Ramírez Gómez et al. Lupus. 2008 Jun.

Abstract

To evaluate disease characteristics of childhood onset SLE in Latin America and to compare this information with an adult population in the same cohort of GLADEL. A protocol was designed as a multicenter, multinational, inception cohort of lupus patients to evaluate demographic, clinical, laboratory and serological variables, as well as classification criteria, disease activity, organ damage and mortality. Descriptive statistics, chi square, Fisher's exact test, Student's t test and multiple logistic regression were used to compare childhood and adult onset SLE. 230 patients were <18 years and 884 were adult SLE patients. Malar rash, fever, oral ulcers, thrombocytopenia and hemolytic anemia and some neurologic manifestations were more prevalent in children (p<0.05). On the other hand, myalgias, Sjögren's syndrome and cranial nerve involvement were more frequently seen in adults (p<0.05). Afro-Latin-American children had a higher prevalence of fever, thrombocytopenia and hemolytic anemia. White and mestizo children had a higher prevalence of malar rash. Mestizo children had a higher prevalence of cerebrovascular disease and cranial nerve involvement. Children met SLE ACR criteria earlier with higher mean values than adults (p: 0.001). They also had higher disease activity scores (p: 0.01), whereas adults had greater disease damage (p: 0.02). In Latin America, childhood onset SLE seems to be a more severe disease than adults. Some differences can be detected among ethnic groups.

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