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Review
. 2008 Jun 10;26(17):2883-9.
doi: 10.1200/JCO.2007.15.2702.

Cancer stem cells and the ontogeny of lung cancer

Craig D Peacock  1 , D Neil Watkins
Affiliations
Review

Cancer stem cells and the ontogeny of lung cancer

Craig D Peacock et al. J Clin Oncol. .

Abstract

Lung cancer is the leading cause of cancer death in the world today and is poised to claim approximately 1 billion lives during the 21st century. A major challenge in treating this and other cancers is the intrinsic resistance to conventional therapies demonstrated by the stem/progenitor cell that is responsible for the sustained growth, survival, and invasion of the tumor. Identifying these stem cells in lung cancer and defining the biologic processes necessary for their existence is paramount in developing new clinical approaches with the goal of preventing disease recurrence. This review summarizes our understanding of the cellular and molecular mechanisms operating within the putative cancer-initiating cell at the core of lung neoplasia.

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Conflict of interest statement

AUTHORS’ DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

The author(s) indicated no potential conflicts of interest.

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