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Review
. 2008 Jul-Aug;129(7-8):441-8.
doi: 10.1016/j.mad.2008.04.009. Epub 2008 Apr 30.

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Tinna Stevnsner  1 , Meltem Muftuoglu, Maria Diget Aamann, Vilhelm A Bohr
Affiliations
Review

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Tinna Stevnsner et al. Mech Ageing Dev. 2008 Jul-Aug.

Abstract

Cockayne Syndrome (CS) is a rare human genetic disorder characterized by progressive multisystem degeneration and segmental premature aging. The CS complementation group B (CSB) protein is engaged in transcription coupled and global nucleotide excision repair, base excision repair and general transcription. However, the precise molecular function of the CSB protein is still unclear. In the current review we discuss the involvement of CSB in some of these processes, with focus on the role of CSB in repair of oxidative damage, as deficiencies in the repair of these lesions may be an important aspect of the premature aging phenotype of CS.

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Figures

Fig. 1
Fig. 1
Characteristic motifs of the CSB protein. Mutants that are discussed in the review are indicated.
Fig. 2
Fig. 2
Pathways in which CSB might participate - based on proteins which have been demonstrated to interact with CSB.
See this image and copyright information in PMC

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