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. 1991 May;35(5):983-5.
doi: 10.1128/AAC.35.5.983.

Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam

M L van Ogtrop  1 , H F Guiot, H Mattie, E van Strijen, B R Sekh, R van Furth
Affiliations

Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam

M L van Ogtrop et al. Antimicrob Agents Chemother. 1991 May.

Abstract

Oral and parenteral administration of aztreonam and oral administration of tigemonam to conventional mice caused a decrease in the number of aerobic gram-negative rods in the feces. Oral treatment with high doses of aztreonam (greater than or equal to 25 mg/kg/day) and tigemonam (100 mg/kg/day) adversely influenced colonization resistance, whereas oral treatment with lower doses of the monobactams or parenteral treatment with aztreonam did not.

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References

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