doi: 10.1007/978-1-60327-058-8_8.
Protein structure modeling with MODELLER
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- PMID: 18542861
- DOI: 10.1007/978-1-60327-058-8_8
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Protein structure modeling with MODELLER
Methods Mol Biol.
2008.
Abstract
Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protocols (correction of protcols) has resulted in models of useful accuracy for domains in more than half of all known protein sequences.
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