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. 2008 Jul 9;130(27):8600-1.
doi: 10.1021/ja802946s. Epub 2008 Jun 11.

Active trifluoromethylating agents from well-defined Copper(I)-CF3 complexes

Galyna G Dubinina  1 , Hideki Furutachi, David A Vicic
Affiliations

Active trifluoromethylating agents from well-defined Copper(I)-CF3 complexes

Galyna G Dubinina et al. J Am Chem Soc. .

Abstract

The first examples of isolable and structurally characterized Cu(I)-CF3 complexes are reported. N-Heterocyclic carbene (NHC)-supported copper tert-butoxide complexes reacted with Me3Si-CF3 to afford new (NHC)Cu-CF3 complexes whose structures were dependent on whether or not the C4-C5 positions of the five-membered NHC rings were saturated. In situ generated (SIiPr)Cu-CF3 cleanly transferred its trifluoromethyl group to a number of organic halides under mild conditions.

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