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Review
. 2008 Jun;14(2):179-86.
doi: 10.1089/ten.teb.2008.0038.

Modulation of the inflammatory response for enhanced bone tissue regeneration

Paschalia M Mountziaris  1 , Antonios G Mikos
Affiliations
Review

Modulation of the inflammatory response for enhanced bone tissue regeneration

Paschalia M Mountziaris et al. Tissue Eng Part B Rev. 2008 Jun.

Abstract

Proinflammatory cytokines are infamous for their catabolic effects on tissues and joints in both inflammatory diseases and following the implantation of biomedical devices. However, recent studies indicate that many of these same molecules are critical for triggering tissue regeneration following injury. This review will discuss the role of inflammatory signals in regulating bone regeneration and the impact of both immunomodulatory and antiinflammatory pharmacologic agents on fracture healing, to demonstrate the importance of incorporating rational control of inflammation into the design of tissue engineering strategies.

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Figures

FIG. 1.
FIG. 1.
Schematic depicting the temporal pattern expression of three proinflammatory signals, tumor necrosis factor α (TNF-α), interleukin-1 (IL-1), and IL-6, after bone injury. The levels of each molecule are expressed as a percentage of the maximal level observed over the time period indicated. This graphic representation does not indicate concentrations of one molecule relative to another. Schematic is based on quantitative analysis of in vivo mRNA expression following bone injury.,
See this image and copyright information in PMC

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