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Comment
. 2008 Jun 15;111(12):5418-9.
doi: 10.1182/blood-2008-02-140962.

Follicular lymphomas and histiocytic/dendritic neoplasms related?

Jonathan Said  1
Affiliations
Comment

Follicular lymphomas and histiocytic/dendritic neoplasms related?

Jonathan Said. Blood. .

Abstract

In this issue of Blood, Feldman and colleagues provide convincing evidence of a clonal relationship between follicular lymphoma and H/DC sarcoma, suggesting plasticity between these apparently disparate lineages with implications for transformation events in malignant lymphomas.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests. ■

Figures

None
Follicular dendritic-cell sarcoma with syncytial proliferation of spindle cells. Note the characteristic sprinkling of lymphocytes within the tumor. The inset shows the ultrastructural appearance of dendritic cells with villous cell processes and prominent lysosomal granules.
See this image and copyright information in PMC

Comment on

References

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    1. Paquette RL, Hsu N, Said J, et al. Interferon-alpha induces dendritic cell differentiation of CML mononuclear cells in vitro and in vivo. Leukemia. 2002;16:1484–1489. - PubMed