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. 2008 Jul 15;18(14):4249-52.
doi: 10.1016/j.bmcl.2008.02.020. Epub 2008 Feb 10.

Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length

Shuichi Mori  1 , Shinya Miyake, Takayoshi Kobe, Takaaki Nakaya, Stephen D Fuller, Nobuo Kato, Kunihiro Kaihatsu
Affiliations

Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length

Shuichi Mori et al. Bioorg Med Chem Lett. .

Abstract

A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG.

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