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. 2009 Feb;44(2):862-8.
doi: 10.1016/j.ejmech.2008.04.021. Epub 2008 May 9.

Targeting cancer cells with biotin-dendrimer conjugates

Wenjun Yang  1 , Yiyun Cheng, Tongwen Xu, Xueyuan Wang, Long-Ping Wen
Affiliations

Targeting cancer cells with biotin-dendrimer conjugates

Wenjun Yang et al. Eur J Med Chem. 2009 Feb.

Abstract

Star-burst dendrimers represent a superior carrier platform for targeted drug delivery. Partially acetylated generation 5 (G5) polyamidoamine (PAMAM) dendrimer was conjugated with the targeting moiety (biotin) and the imaging moiety (fluoresceinisothiocyanate, FITC), and the resulting dendrimer-biotin conjugate was characterized by (1)H NMR, UV-vis spectrum. As revealed by flow cytometry and confocal microscopy, the bifunctional conjugate (dendrimer-biotin-FITC) exhibited much higher cellular uptake into HeLa cells than the conjugate without biotin. The uptake was energy-dependent, dose-dependent, and could be effectively blocked by dendrimer-conjugated biotin. Our results indicated that the biocompatible biotin-dendrimer conjugate might be a promising nano-platform for cancer therapy and cancer diagnosis.

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