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. 2008 Jul;72(1):3-15.
doi: 10.1111/j.1747-0285.2008.00673.x. Epub 2008 Jun 11.

Natural compounds: leads or ideas? Bioinspired molecules for drug discovery

Terence Beghyn  1 , Rebecca Deprez-Poulain, Nicolas Willand, Benoit Folleas, Benoit Deprez
Affiliations

Natural compounds: leads or ideas? Bioinspired molecules for drug discovery

Terence Beghyn et al. Chem Biol Drug Des. 2008 Jul.

Abstract

In this article, we compare drugs of natural origin to synthetic compounds and analyze the reasons why natural compounds occupy a place of choice in the current pharmacopoeia. The observations reported here support the design of synthetic compounds inspired from plant alkaloids and their biosynthetic pathway. Our reasoning leads to very efficient syntheses of compounds which complexity matches that of indolomonoterpenic alkaloids.

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