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Comment
. 2008 Aug;49(2):299-300.
doi: 10.1016/j.jhep.2008.05.008. Epub 2008 May 23.

Perspectives for the utilization of neutralizing human monoclonal antibodies as anti-HCV drugs

Roberto Burioni  1 , Mario Perotti, Nicasio Mancini, Massimo Clementi
Affiliations
Comment

Perspectives for the utilization of neutralizing human monoclonal antibodies as anti-HCV drugs

Roberto Burioni et al. J Hepatol. 2008 Aug.

Abstract

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver-chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.

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