Correlation of antimüllerian hormone and baseline follicle-stimulating hormone levels

Abstract

Objective: To compare how a given level of antimüllerian hormone (AMH) might be used to predict the level of FSH.

Design: Retrospective cohort study.

Setting: Academically affiliated private fertility center.

Patient(s): Eighty-one women in preparation for an IVF cycle.

Intervention(s): None.

Main outcome measure(s): Levels of FSH and AMH before start of ovulation induction.

Result(s): Serum AMH and log-converted FSH levels were negatively correlated (R(2) = 0.42). The linear regression model for FSH, based on random AMH, was as follows: LnFSH = 2.3 + -0.25 x lnAMH; 95% confidence limits of the coefficient 0.-32 to 0.-18, suggesting that an AMH level of 0.5 ng/mL is predictive of a baseline FSH level of 12.1 mIU/mL (95% confidence interval 11.4-12.7 mIU/mL).

Conclusion(s): These data demonstrate a statistical association between FSH and AMH in assessing ovarian reserve. Using FSH and AMH in combination may improve the evaluation of ovarian reserve. However, it remains to be determined which of these two ovarian function parameters is superior in assessing ovarian reserve with a single test and which test, or combination of tests, will in the future be used in routine infertility evaluations.