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Comment
. 2008 Jun 13;133(6):947-8.
doi: 10.1016/j.cell.2008.05.035.

Rewiring bacteria, two components at a time

Michael A Kohanski  1 , James J Collins
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Rewiring bacteria, two components at a time

Michael A Kohanski et al. Cell. .
Free article

Abstract

In this issue, Skerker et al. (2008) present a rational method for rewiring the protein-protein interactions and output responses of prokaryotic two-component signal transduction systems. This work has important implications for understanding the specificity of protein interactions and for designing protein-based synthetic signaling cascades.

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