Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2008 Nov;89(2):150-5.
doi: 10.1016/j.radonc.2008.05.018. Epub 2008 Jun 13.

Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction

Palmira Foro Arnalot  1 , Agustí Valls Fontanals, Joan Carles Galcerán, Frances Lynd, Xavier Sanz Latiesas, Nuria Rodríguez de Dios, Anna Reig Castillejo, Marti Lacruz Bassols, Joan Lozano Galán, Ismael Membrive Conejo, Manuel Algara López
Affiliations
Randomized Controlled Trial

Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction

Palmira Foro Arnalot et al. Radiother Oncol. 2008 Nov.

Abstract

Background and purpose: The aim was to demonstrate similar pain relief with two schedules of radiotherapy for painful bone metastases.

Materials and methods: A total of 160 patients were assigned to receive a single 8-Gy fraction or 30 Gy in 10 fractions. Pain intensity was measured on an ordinal pain scale of 0-10. Partial response was defined as a pain reduction of two points or more and complete response as a pain score of zero at the treated area. Response follow-up was at 3, 12, 24 and 48 weeks.

Results: The overall response was 75% in the 8-Gy arm and 86% in the 30-Gy arm. Complete response and partial response rates were 15% and 60% in the 8-Gy arm, 13% and 73% in the 30-Gy arm. Acute toxicity was of 18% in the 30-Gy arm and of 12% in the 8-Gy arm. These differences were not statistically significant. The re-treatment rate was 28% vs 2% in the 8-Gy and 30-Gy arms, respectively, these were statistically significant.

Conclusions: A single-fraction regimen of 8 Gy was as safe and effective as a multifraction regimen of 30 Gy for painful bone metastases in terms of pain relief.

PubMed Disclaimer

Publication types