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Comment
. 2008 Jun 13;320(5882):1433-4.
doi: 10.1126/science.1159651.

Physiology. Unfolding lipid metabolism

Jay D Horton  1
Affiliations
Comment

Physiology. Unfolding lipid metabolism

Jay D Horton. Science. .
No abstract available

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Figures

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Regulators of lipid synthesis and the unfolded protein response
The transcription factors XBP1, ATF6, and SREBP require processing to active forms before entering the nucleus, where SERBPs and XBP1 control the expression of genes involved in lipogenesis and ATF6 activates XBP1. The activation of XBP1 and ATF6 in response to stress occurs independently of the regulation of SREBPs by cholesterol.
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References

    1. Zhao L, Ackerman SL. Curr Opin Cell Biol. 2006;18:444. - PubMed
    1. Lee AH, Scapa EF, Cohen DE, Glimcher LH. Science. 2008;320:1492. - PMC - PubMed
    1. Reimold AM, et al. Genes Dev. 2000;14:152. - PMC - PubMed
    1. Horton JD, Goldstein JL, Brown MS. J Clin Invest. 2002;109:1125. - PMC - PubMed
    1. Goldstein JL, Rawson RB, Brown MS. Arch Biochem Biophys. 2002;397:139. - PubMed

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