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Case Reports
. 2008 Jul;184(1):57-61.
doi: 10.1016/j.cancergencyto.2008.03.010.

Deletion of chromosome arm 15q in a case of minimally differentiated hypoplastic AML-M0

Atsushi Fujieda  1 , Masahiro Masuya, Shigehisa Kitano, Kana Miyazaki, Akira Yazaki, Yuka Sugimoto, Eiji Usui, Eri Miyata, Tetsunori Shibasaki, Kentaro Yamamura, Kohshi Ohishi, Kazuhiro Nishii, Kazunori Nakase, Toshiaki Takeuchi, Naoyuki Katayama
Affiliations
Case Reports

Deletion of chromosome arm 15q in a case of minimally differentiated hypoplastic AML-M0

Atsushi Fujieda et al. Cancer Genet Cytogenet. 2008 Jul.

Abstract

Deletion of the long arm of chromosome 15 is known as a rare but recurrent chromosomal abnormality in myeloid malignancies. We report a novel case of minimally differentiated hypoplastic acute myeloid leukemia (AML M0) in a patient who initially had a normal karyotype, but clonal interstitial deletion of chromosome 15, del(15)(q11.2q22), coincided with increment of leukemic cells a year later. We also summarize 18 published cases with myeloid malignancies and this chromosomal abnormality.

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