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Review
. 2008 Jul;119(1):33-43.
doi: 10.1016/j.pharmthera.2008.04.006. Epub 2008 May 16.

Synthesis, trafficking, and localization of muscarinic acetylcholine receptors

Neil M Nathanson  1
Affiliations
Review

Synthesis, trafficking, and localization of muscarinic acetylcholine receptors

Neil M Nathanson. Pharmacol Ther. 2008 Jul.

Abstract

Muscarinic acetylcholine receptors are members of the G-protein coupled receptor superfamily that are expressed in and regulate the function of neurons, cardiac and smooth muscle, glands, and many other cell types and tissues. The correct trafficking of membrane proteins to the cell surface and their subsequent localization at appropriate sites in polarized cells are required for normal cellular signaling and physiological responses. This review will summarize work on the synthesis and trafficking of muscarinic receptors to the plasma membrane and their localization at the cell surface.

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Figures

Figure 1
Figure 1
Muscarinic receptor sorting signals. TOP: The approximate location of the targeting signals in both the M2 and M3 receptors is depicted by the thick line in the third cytoplasmic loop. BOTTOM: The amino acid sequences of the basolateral sorting signal in the M3 receptor and the apical sorting signal in the M2 receptor.
See this image and copyright information in PMC

References

    1. Abrams P, Andersson KE, Buccafusco J, Chapple C, de Groat WC, Fryer A, Kay G, Laties A, et al. Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Brit J Pharmacol. 2006;148:565–578. - PMC - PubMed
    1. Adair-Kirk TL, Dorsey FC, Cox JV. Multiple cytoplasmic signals direct the intracellular trafficking of chicken kidney AE1 anion exchangers in MDCK cells. J Cell Sci. 2003;15:655–663. - PubMed
    1. Alcantara AA, Mrzljak L, Jakab RL, Levey AI, Hersch SM, Goldman-Rakic PS. Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: anatomical evidence for cholinergic modulation of glutamatergic prefrontostriatal pathways. J Comp Neurol. 2001;434:445–460. - PubMed
    1. Ashby MC, Camello-Almaraz C, Gerasimenko OV, Petersen OH, Tepikin AV. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. J Biol Chem. 2003;278:20860–20864. - PubMed
    1. Ashkenazi A, Winslow JW, Peralta EG, Peterson GL, Schimerlik MI, Capon DJ, et al. A single M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science. 1987;238:672–675. - PubMed

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