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. 2008 Aug 1;47(3):388-90.
doi: 10.1086/589864.

Genetic diversity and antimicrobial resistance in group B streptococcus colonizing young, nonpregnant women

Shannon D Manning  1 , Katherine E Schaeffer, A Cody Springman, Erica Lehotzky, Maggi A Lewis, Lindsey M Ouellette, Guangxi Wu, Glynda M Moorer, Thomas S Whittam, H Dele Davies
Affiliations

Genetic diversity and antimicrobial resistance in group B streptococcus colonizing young, nonpregnant women

Shannon D Manning et al. Clin Infect Dis. .

Abstract

The genetic diversity of group B Streptococcus in young, nonpregnant women is not well studied. Application of multilocus sequence analysis to 85 group B Streptococcus strains recovered from college students revealed similarities and differences in distribution of group B Streptococcus lineages, compared with that of previously studied pregnant populations, and revealed that strains of 1 clone were associated with antibiotic resistance.

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Conflict of interest statement

Potential conflicts of interest. All authors: no conflicts.

Figures

Figure 1.
Figure 1.
Distribution of antibiotic resistance in 85 group B Streptococcus strains isolated from nonpregnant women and stratified by multilocus sequence type (ST) and capsule (cps) genotype. The cps type is denoted as 1a, 1b, or 2–6 to the left of the representative portion of each bar. ST-1 cps5 (serotype V) strains were more frequently resistant, whereas ST-8 cps1b (serotype Ib) strains were more frequently susceptible, relative to all other ST and cps combinations. *ST-23 (n = 12) and ST-23 variants (n = 3) were included as 1 group; 1 ST-22 variant was identified and is included with the ST-22 group as well. v, ST variant.
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References

    1. Davies HD, Adair C, McGeer A, et al. Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: relationship to colonization status and infection in the neonate. J Infect Dis 2001; 184:285–91. - PubMed
    1. Manning SD, Neighbors K, Tallman PA, et al. Prevalence of group B Streptococcus colonization and potential for transmission by casual contact in healthy young men and women. Clin Infect Dis 2004; 39:380–8. - PubMed
    1. Zaleznik DF, Rench MA, Hillier S, et al. Invasive disease due to group B Streptococcus in pregnant women and neonates from diverse population groups. Clin Infect Dis 2000;30:276–81. - PubMed
    1. Harrison LH, Elliott JA, Dwyer DM, et al. Serotype distribution of invasive group B streptococcal isolates in Maryland: implications for vaccine formulation. J Infect Dis 1998; 177:998–1002. - PubMed
    1. Manning SD, Lewis MA, Springman AC, Lehotzky E, Whittam TS, Davies HD. Genotypic diversity and serotype distribution of group B Streptococcus isolated from women before and after delivery. Clin Infect Dis 2008;46:1829–37. - PMC - PubMed

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