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Meta-Analysis
. 2008 Nov;136(11):1441-7.
doi: 10.1017/S0950268808000770. Epub 2008 Jun 18.

Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: a systematic review

M R Hoek  1 , H Christensen, W Hellenbrand, P Stefanoff, M Howitz, J M Stuart
Affiliations
Meta-Analysis

Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: a systematic review

M R Hoek et al. Epidemiol Infect. 2008 Nov.

Abstract

SUMMARYWe performed a systematic review to estimate the effectiveness of vaccination, in addition to chemoprophylaxis, in preventing meningococcal disease among household contacts. Medline, EMBASE, EMGM, and EUIBIS were used for data collection. Studies reporting on at least 100 primary cases and on subsequent cases in household settings with follow-up of more than 2 weeks after onset of disease in the primary case were reviewed. A meta-analysis was used to calculate the average attack rate in household contacts given chemoprophylaxis 14-365 days after onset of disease in the primary case. In total, 652 studies were identified, five studies and one unpublished report met the inclusion criteria. The weighted average attack rate was 1.1/1000 household contacts (95% CI 0.7-1.7). This review supports vaccination of household contacts in addition to chemoprophylaxis to reduce the risk of meningococcal disease among household contacts of a case caused by a vaccine-preventable serogroup.

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Figures

Fig. 1
Fig. 1
Progress through the stages of the literature review.
See this image and copyright information in PMC

References

    1. Ramsay M, Fox A, Chandra M. Invasive Neisseria meningitidis in Europe. European Union Invasive Bacterial Infectious Surveillance Network, 2003http://www.euibis.org
    1. Borg J et al. Outcomes of meningococcal disease during the teenage peak. Archives of Diseases in Childhood. 2003;88:426–429.
    1. Wang VJ et al. Meningococcal disease among children who live in a large metropolitan area, 1981–1996. Clinical Infectious Disease. 2001;32:1004–1009. - PubMed
    1. De Wals P et al. Meningococcal disease in Belgium. Secondary attack rate among household, day-care nursery and pre-elementary school contacts. Journal of Infection. 1981;3:53–61. - PubMed
    1. Munford RS et al. Spread of meningococcal infection within households. Lancet. 1974;1:1275–1278. - PubMed

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