Comment
doi: 10.1016/j.chembiol.2008.06.001.
Geometry shapes cell signaling network output
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- PMID: 18559261
- DOI: 10.1016/j.chembiol.2008.06.001
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Comment
Geometry shapes cell signaling network output
Chem Biol.
2008 Jun.
Abstract
Through live cell imaging and computational modeling, Neves et al. (2008) demonstrate that molecular interactions alone are insufficient to explain the patterns of MAPK activation: a model must include the cell morphology and spatial distribution of signaling molecules.
Comment on
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Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.Cell. 2008 May 16;133(4):666-80. doi: 10.1016/j.cell.2008.04.025. Cell. 2008. PMID: 18485874 Free PMC article.
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