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. 2008 Jun 15;14(12):3643-5.
doi: 10.1158/1078-0432.CCR-08-1135.

Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program

Patricia S Steeg  1
Affiliations

Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program

Patricia S Steeg. Clin Cancer Res. .
No abstract available

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Figures

Figure 1
Figure 1
Representative Cases from a Rapid Autopsy Program (10). Metastases were harvested within four hours of death from ten patients and compared to the matched primary tumor. The results from two cases are diagrammed. IHC staining for estrogen receptor (ER) and progesterone receptor (PR) is based on the percentage of positive cells; that for EGF Receptor (EGFR) and c-Met (MET) is on a 0-3+ intensity scale; and Cox-2 is positive/negative. Percentage DNA methylation of gene promoters was determined by QM-MSP assay. Methylation of the HIN1, Twist and ERα genes was relatively uniform in all samples.
See this image and copyright information in PMC

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