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. 2008 Jun;63(6):635-41.
doi: 10.1093/gerona/63.6.635.

Trace element levels and cognitive function in rural elderly Chinese

Sujuan Gao  1 , Yinlong Jin, Frederick W Unverzagt, Feng Ma, Kathleen S Hall, Jill R Murrell, Yibin Cheng, Jianzhao Shen, Bo Ying, Rongdi Ji, Janetta Matesan, Chaoke Liang, Hugh C Hendrie
Affiliations

Trace element levels and cognitive function in rural elderly Chinese

Sujuan Gao et al. J Gerontol A Biol Sci Med Sci. 2008 Jun.

Abstract

Background: Trace elements are involved in metabolic processes and oxidation-reduction reactions in the central nervous system and could have a possible effect on cognitive function. The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively.

Methods: The participant population is part of a large cohort study of 2000 rural elderly Chinese persons. Six cognitive assessment tests were used to evaluate cognitive function in this population, and a composite score was created to represent global cognitive function. Trace element levels of aluminum, calcium, cadmium, copper, iron, lead, and zinc were analyzed in plasma samples of 188 individuals who were randomly selected and consented to donating fasting blood. Analysis of covariance models were used to assess the association between each trace element and the composite cognitive score adjusting for demographics, medical history of chronic diseases, and the apolipoprotein E (APOE) genotype.

Results: Three trace elements-calcium, cadmium, and copper-were found to be significantly related to the composite cognitive score. Increasing plasma calcium level was associated with higher cognitive score (p <.0001). Increasing cadmium and copper, in contrast, were significantly associated with lower composite score (p =.0044 and p =.0121, respectively). Other trace elements did not show significant association with the composite cognitive score.

Conclusions: Our results suggest that calcium, cadmium, and copper may be associated with cognitive function in the elderly population.

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Figures

Figure 1
Figure 1
Scatter plots of the composite z score versus each trace element.
Figure 2
Figure 2
Mean composite z score in the low cadmium group (plasma cadmium level = 0.05 μg/L) and in the high cadmium group (plasma cadmium level > 0.05 μg/L).
See this image and copyright information in PMC

References

    1. Goldstein GW. Lead poisoning and brain cell function. Environ Health Perspect. 1990;89:91–94. - PMC - PubMed
    1. Bourre JM. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: Micronutrients. J Nutr Health Aging. 2006;10:377–385. - PubMed
    1. Sutoo D, Akiyama K. Regulation of brain function by exercise. Neurobiol Dis. 2003;13:1–14. - PubMed
    1. Huang X, Cuajungco MP, Atwood CS, et al. Cu(ii) potentiation of Alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem. 1999;274:37111–37116. - PubMed
    1. Munoz DG. Is exposure to aluminum a risk factor for the development of Alzheimer disease?–No. Arch Neurol. 1998;55:737–739. - PubMed

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