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. 2008 Aug 1;440(2):190-2.
doi: 10.1016/j.neulet.2008.05.082. Epub 2008 May 27.

No association of SORL1 SNPs with Alzheimer's disease

Ryan L Minster  1 , Steven T DeKosky, M Ilyas Kamboh
Affiliations

No association of SORL1 SNPs with Alzheimer's disease

Ryan L Minster et al. Neurosci Lett. .

Abstract

SORL1 is an element of the amyloid precursor protein processing pathway and is therefore a good candidate for affecting Alzheimer's disease (AD) risk. Indeed, there have been reports of associations between variation in SORL1 and AD risk. We examined six statistically significant single-nucleotide polymorphisms from the initial observation in a large Caucasian American case-controls cohort (1000 late-onset AD [LOAD] cases and 1000 older controls). Analysis of allele, genotype and haplotype frequencies revealed no association with LOAD risk in our cohort.

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