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. 2008 Jun;28(3):349-51.
doi: 10.1007/s11596-008-0328-x. Epub 2008 Jun 19.

Expression of apoptosis related protein in skin lesions of lichen planus and its implication

Xu'e Chen  1 , Yan Wu, Jiawen Li, Zhixiang Liu, Qing Yue, Houjun Liu
Affiliations

Expression of apoptosis related protein in skin lesions of lichen planus and its implication

Xu'e Chen et al. J Huazhong Univ Sci Technolog Med Sci. 2008 Jun.

Abstract

In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.

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