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Review
. 2008 Oct 3;283(40):26829-33.
doi: 10.1074/jbc.R800037200. Epub 2008 Jun 19.

Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

R John Solaro  1
Affiliations
Review

Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

R John Solaro. J Biol Chem. .
No abstract available

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Figures

FIGURE 1.
FIGURE 1.
Kinases affecting sarcomeric proteins. Major substrates for these kinases are illustrated in a region of overlap between thin actin-containing and thick myosin-containing filaments. Also shown is a portion of the network of proteins at the Z-disk, which houses docking sites (e.g. ZASP) for kinases. Thin filaments terminate in the Z-disk and are capped by CapZ; thick filaments connect to the Z-disk network via the giant elastic (PEVK region) protein, titin. See text for details. ANP, atrial natriuretic peptide; β-AR, β-adrenergic receptor; LPA, lysophosphatidic acid; S1P, sphingosine 1-phosphate; ET-1, endothelin-1; Ang II, angiotensin II; BK, bradykinin; ACh, acetylcholine; ECC, excitation-contraction coupling; CaMK, calmodulin kinase; MHC, myosin heavy chain; MLC, myosin light chain.
See this image and copyright information in PMC

References

    1. Bers, D. M. (2001) Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd Ed., Kluwer Academic Publishers, Norwell, MA
    1. Kobayashi, T., and Solaro, R. J. (2005) Annu. Rev. Physiol. 67 39–67 - PubMed
    1. Hinken, A., and Solaro, R. J. (2007) Physiology 22 73–80 - PubMed
    1. Solaro, R. J. (2001) in Handbook of Physiology (Page, E., Fozzard, H., and Solaro, R. J., eds) Section 2, Vol. 1, pp. 264–300, Oxford University Press, New York
    1. Metzger, J. M., and Westfall, M. V. (2004) Circ. Res. 94 146–158 - PubMed

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