Review
doi: 10.1038/nrm2434.
Cytochrome c: functions beyond respiration
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- PMID: 18568041
- DOI: 10.1038/nrm2434
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Review
Cytochrome c: functions beyond respiration
Nat Rev Mol Cell Biol.
2008 Jul.
Abstract
Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family. As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions.
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