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Randomized Controlled Trial
. 2008;26(2):106-10.
doi: 10.1080/02813430802005894.

Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS). A double-blind, randomized study

Rickard Ekesbo  1 , Peter M Nilsson, Kristina Sjölund
Affiliations
Randomized Controlled Trial

Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS). A double-blind, randomized study

Rickard Ekesbo et al. Scand J Prim Health Care. 2008.

Abstract

Objective: To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS).

Design: A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study.

Subjects: Eighty-two patients with IBS were randomized to a diet with either SPC or placebo.

Main outcome measures: The overall clinical condition and the quality of life were measured by VAS and SF-36 questionnaire, respectively. The plasma levels of ASF were determined in 14 patients with dominating loose stools before and after diet.

Results: All patients significantly (p<0.001) improved in IBS-related symptoms irrespective of active or placebo diet. In an active-diet sub-group with diarrhoea (n=11) there was a significant (p<0.05) correlation between the increase of plasma ASF level and the improvement on the VAS.

Conclusion: Both study groups improved significantly on the VAS but no additive effect was seen for the active treatment. In the sub-group with loose stools, the SPC diet induced ASF plasma levels in IBS patients and was correlated to significant symptom improvement in the individual patient.

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