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. 2008 Sep;43(1):9-12.
doi: 10.1016/j.jcv.2008.05.002. Epub 2008 Jun 20.

"Is it the cause?"--Robert Koch and viruses in the 21st century

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"Is it the cause?"--Robert Koch and viruses in the 21st century

Charles Richard Madeley. J Clin Virol. 2008 Sep.

Abstract

Confirmation that a virus is genuinely the cause of a disease is unexpectedly difficult, especially with new molecular approaches to diagnosis. This paper discusses the problems, which are closely related to the methods used to detect virus (or components of virus), and suggests that longitudinal studies are essential to confirming causation and avoiding unwarranted assumptions.

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