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Review
. 2007;61(4):739-45.

Central nervous system as a possible site of HCV replication

Agnieszka Bednarska  1 , Andrzej Horban, Marek Radkowski
Affiliations
  • PMID: 18572506
Review

Central nervous system as a possible site of HCV replication

Agnieszka Bednarska et al. Przegl Epidemiol. 2007.

Abstract

There is mounting evidence of HCV neuroinvasion on the clinical and molecular level. It seems that microglia cells, representing a resident CNS macrophages population, are the main target for the virus. It can be also speculated that the macrophages carry HCV to CNS compartment. Nonspecific inflammation and changes in the metabolic pathway of infected cells can play a role in pathogenesis of neurological symptoms which are observed in HCV infected patients.

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