Review
doi: 10.1111/j.1365-2958.2008.06335.x.
Epub 2008 Jun 28.
Holin of bacteriophage lambda: structural insights into a membrane lesion
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- PMID: 18573181
- DOI: 10.1111/j.1365-2958.2008.06335.x
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Review
Holin of bacteriophage lambda: structural insights into a membrane lesion
Mol Microbiol.
2008 Aug.
Free article
Abstract
The length of the infection cycle of double-stranded DNA bacteriophages is controlled by phage-encoded small integral membrane proteins, holins. Holins are the gatekeepers of the lysis process, possessing an intriguing ability to be triggered, at a precise time point, to form large holes in the cytoplasmic membrane of phage-infected bacteria. The paper by Savva et al. in this issue of Molecular Microbiology invites us to take a closer look at this membrane lesion. For the first time, a structural characterization of large-diameter rings formed by these peculiar membrane proteins is presented.
Comment on
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The holin of bacteriophage lambda forms rings with large diameter.Mol Microbiol. 2008 Aug;69(4):784-793. doi: 10.1111/j.1365-2958.2008.06298.x. Mol Microbiol. 2008. PMID: 18788120 Free PMC article.
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