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. 2008 Sep;52(9):3427-9.
doi: 10.1128/AAC.00493-08. Epub 2008 Jun 23.

The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae

Louis B Rice  1 , Lenore L Carias, Rebecca A Hutton, Susan D Rudin, Andrea Endimiani, Robert A Bonomo
Affiliations

The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae

Louis B Rice et al. Antimicrob Agents Chemother. 2008 Sep.

Abstract

The bla(KPC-3) and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae.

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Figures

FIG. 1.
FIG. 1.
(A) Relative positions of the different putative mobile elements within the KQ element. The Tn1331 backbone is designated by the hatched areas. The positions of insertion of Tn4401 and Tn5387 are indicated. The positions of different restriction sites are also indicated. (B) Representation of the different mobile elements comprising the KQ element. The names of the individual element are indicated at the left. The left and right vertical arrows represent the insertion sites for Tn4401 and Tn5387, respectively. IS elements are boxed, and the arrows reflect the direction of transcription of their transposase genes. The locations of PCR primers KPCoutREV (arrow A) and PCR543r (arrow B) are indicated.
See this image and copyright information in PMC

References

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