Review
doi: 10.1038/cr.2008.74.
Actions of human telomerase beyond telomeres
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- PMID: 18574498
- DOI: 10.1038/cr.2008.74
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Review
Actions of human telomerase beyond telomeres
Cell Res.
2008 Jul.
Abstract
Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stem cell function, and in the regulation of gene expression.
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