[Genetic control over the determination and proliferation of melanocyte stem cells in mammals]

Abstract

Data obtained in mutant mouse strains provide evidence for multilocus control of determination and proliferation of melanocyte stem cells. Mice are known to have five loci (mi, Sp, s, Ls, Dom) controlling melanoblast determination. Locus mi is expressed in pluripotent cells of the neural crest from which melanocyte and neuron clones are formed; it is also expressed in a strain of ectomesenchyme cells. Loci Sp, s, ls and Dom are expressed somewhat later, probably during one of the last quantal cell cycles leading to the determination of unipotent melanocyte stem cells. Mutant genes of these loci impair the development of pigment cells as well as of ganglial neurons. Three loci (W, vs, Sl) control the proliferation of melanocyte stem cells. Mutations of locus W present in a single copy inhibit the proliferative activity of melanoblasts, whereas when present at the double dose they completely block their proliferation. Locus Sl is not expressed in melanocytes but acts in another cell system, which is very important for the proliferation of melanocyte stem cells. Mutant genes Ga, si and vit decrease the lifespan of stem cells for epidermal melanocytes.