Review
Sarcoidosis occuring during anti-TNF-alpha treatment for inflammatory rheumatic diseases: report of two cases
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- PMID: 18578973
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Review
Sarcoidosis occuring during anti-TNF-alpha treatment for inflammatory rheumatic diseases: report of two cases
Clin Exp Rheumatol.
2008 May-Jun.
Abstract
Anti-TNF-alpha agents have been tried in cases of refractory sarcoidosis, giving favourable results. Thus, the occurrence of a granulomatous disease in a patient receiving such drug seems paradoxical. We describe 2 patients with inflammatory rheumatic disease, the first with ankylosing spondylitis, the second with rheumatoid arthritis, under anti-TNF-alpha treatment (infliximab and etanercept respectively) who developed non-caseating granulomas of the lungs and lymph nodes consistent with the diagnosis of sarcoidosis. Limited and various similar cases have been reported. It is generally considered that these granulomatous diseases are related to the anti-TNF-alpha agent.
Comment in
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Development of sarcoidosis during anti-TNF-alpha treatment: what is the mechanism?Clin Exp Rheumatol. 2009 Nov-Dec;27(6):1054; author reply 1055. Clin Exp Rheumatol. 2009. PMID: 20149330 No abstract available.
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