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. 2008 Jul 15;18(14):3925-8.
doi: 10.1016/j.bmcl.2008.06.031. Epub 2008 Jun 13.

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

Christopher M Tegley  1 , Vellarkad N Viswanadhan, Kaustav Biswas, Michael J Frohn, Tanya A N Peterkin, Catherine Chang, Roland W Bürli, Jennifer H Dao, Henrike Veith, Norma Rogers, Sean C Yoder, Gloria Biddlecome, Philip Tagari, Jennifer R Allen, Randall W Hungate
Affiliations

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

Christopher M Tegley et al. Bioorg Med Chem Lett. .

Abstract

Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.

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